Leprosy Classification, Clinical Features, Epidemiology, and Host Immunological Responses: Failure of Eradication in 2023

Leprosy is of big concern in the medical fraternity. also known as Hansen’s disease. It a curable communicable disease that remains prevalent most countries all over globe. chronic granulomatous infection commonly caused by Mycobacterium leprae and lepromatosis, which mainly show an effect on skin peripheral nerves. To control minimize impact disease, much effort has been put into it for decades. Nearly 0.2 million fresh cases were documented 2017 worldwide spite being declared “eradicated” WHO year 2000. However, impressive achievements have made several countries, including India; still, we are lagging behind ultimate goal final disappearance leprosy. Extensive migration crucial element may transmit leprosy to unaffected areas. Additionally, there areas USA where person-to-person transmission reported without prior history exposure. Recently, instigated new Global Strategy 2021-2030, termed "Towards Zero Leprosy." In this article, review clinical features, epidemiology, transmission, classification, host immunological response, diagnostic challenges.